A teenage girl is recovering from leukaemia after becoming the first patient in the world to receive a pioneering cell-editing treatment.
The 13-year-old, named Alyssa, from Leicester, was diagnosed with T-cell acute lymphoblastic leukaemia, which could not be treated with chemotherapy or a bone marrow transplant.
With no options left, doctors at Great Ormond Street Hospital in London, attempted a groundbreaking experimental therapy in which donated immune T-cells were genetically edited to target her cancer.
The technique, known as base-editing, is the first time a cancer treatment has altered the fundamental building blocks of DNA.
Experts changed the genetic code of immune cells to allow them to hunt down and kill cancerous T-cells while leaving themselves alone.
After just 28 days, Alyssa was in remission and after a second bone marrow transplant to restore her immune system the leukaemia is now undetectable. She is recovering at home and hoping to go back to school soon.
Professor Waseem Qasim, Professor of Cell and Gene Therapy at UCL GOS ICH and Consultant Immunologist at GOSH said: “This is a great demonstration of how, with expert teams and infrastructure, we can link cutting edge technologies in the lab with real results in the hospital for patients.
Prof Waseem Qasim said this ‘paves the way for other new treatments and ultimately better futures for sick children’
“It’s our most sophisticated cell engineering so far and paves the way for other new treatments and ultimately better futures for sick children.”
To create the cells, healthy donor T-cells needed to be engineered in four stages. Firstly, receptors needed to be removed from the donated cells to avoid rejection.
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Next, a “flag” known as CD7 that identifies them as T-cells was removed so that the engineered cells did not end up destroying each other.
In the third step, a second “flag”, called CD52, was snipped away to make the edited cells invisible to drugs given to the patient during the treatment process.
These changes were achieved by “base editing” – chemically converting single nucleotide bases or letters of the DNA code, which carry instructions.
For example, changing the nucleotide bases in the gene for CD7 from a cytosine to a thymine creates the equivalent of a genetic full stop, and stops the immune system attacking T-cells.
Alyssa was diagnosed with T-cell leukaemia in May 2021, after a long period of what the family thought were colds, viruses and general tiredness.
Alyssa decided to donate her hair when she found out she would lose it anyway
Despite months of treatment in hospitals in Leicester and Sheffield medics were unable to get her cancer under control and into remission.
Kiona, Alyssa’s mother said: “We’re on a strange cloud nine to be honest – it’s amazing to be home.
“The doctors have said the first six months are the most important and we don’t want to get too cavalier but we kept thinking ‘If they can just get rid of it, just once, she’ll be ok.’ And maybe we’ll be right.
“Hopefully this can prove the research works and they can offer it to more children – all of this needs to have been for something. It just feels so senseless.
“Alyssa wants to go back to school and that could be a reality soon.”
Clinical trial ongoing
A clinical trial for this treatment is currently open and aims to recruit up to 10 patients with T-cell leukaemia who have exhausted all conventional treatment options.
Dr Robert Chiesa, consultant in bone marrow transplant and CAR T-cell therapy at GOSH, said: “This is quite remarkable, although it is still a preliminary result, which needs to be monitored and confirmed over the next few months.
“The entire team here at GOSH are extremely happy for Alyssa and her family and it’s been a privilege to work with them over the past few months. “
The results are being presented this weekend at the American Society of Haematology annual meeting in New Orleans, US.
Ivana Knoll has rocketed to fame at the World Cup with her risque outfits – but the former Miss Croatia was snapped chatting with security as Croatia faced Brazil in the quarter-finals
Former Miss Croatia Ivana Knoll was stopped by security during Croatia’s clash with Brazil as she continued to sport her skimpy outfits.
Ivana has shot to fame in Qatar thanks to her stunning looks as has followed around her national side. And Knoll wore her most risque look to date as she posed at pitchside with a red bra and high-waisted leather pants paired with red and white chequered accessories.
One snap showed Ivana looking towards the camera as she formed a heart with her hands. However, more snaps show Ivana being confronted by two security officials at the Education City Stadium.
The security staff appeared to ask Ivana to return to her seat, which according to her Instagram story, appeared to be higher up in the stadium.
Ivana Knoll was snapped chatting to security(Image: Michael Zemanek/REX/Shutterstock)
The stunning brunette continued to update fans with sultry snaps from inside the stadium as she revealed a heart with a Croatian flag on her breast. Ivana also shared a couple of snaps on her Instagram page of her full outfit.
She captioned the pictured: “Let’s go to the semi-finals!”
“In character, in manner, in style, in all things the supreme excellence is simplicity’’.
A living witness for this above quote is none other than MP and Leader of the Opposition of Sri Lanka Honorable Sajith Premadasa. A Kids’ Christmas event to remember the birth of Christ the savior was held in Kichilan Reception Hall, Wekanda, Slave Island, Colombo 2 yesterday (10). More than 100 underprivileged Kids and parents from different communities gathered to celebrate Christmas. Children were given gifts of School exercise books and accessories. The Opposition Leader, Honorable Sajith Premadasa was gracing the event as the guest of Honor.
The event was hosted by the President of Lions club of Colombo Grand North, Miss Angel Ragunathan, in collaboration with LNW Media Network UK Ltd. The religious leaders, Deputy Mayor of Colombo Mr. AL Haj M.A.M Iqbal, Mr. Thajudeen, Member of Municipal Council, High-Ranking administrators of Lions Club International organization, intellectuals, Revival Power Ministry Sri Lanka, and Rev Karunasekara of Wellawatte Methodist Church also attended this event.
Honorable Sajith Premadasa’s simplicity towards mankind is remarkable. His voluminous work for the humanity and his compassion for the vulnerable community and his tendency to help the poor are worthless. He is a man who follows his father’s footstep. Looking at his father’s achievements and remarks he moulds himself as a better version of his father, but his endeavor is not based on family nepotism nor ethnic or religion unlike other politicians and presidential aspirants.
At the event yesterday he mentioned that he was so delighted to attend this event as a guest of honor which makes him to feel proud as children are the future of the country, its our responsibility to take care of the needs of children’s education and their nutritional needs. He further said that he was willing to be a part of this project to uplift the needs of the society to create a better future because people’s representatives should work for public welfare. Therefore, he loves to support and encourage such humanitarian services conducted by Lions International Organization.
I would like to mention his father the 3rd president of Sri Lanka Late Mr. Ranasinghe Premadasa was a man who zealously loved his country, much of his attention was directed at governing the country and his concentration on his presidential duties were immense. He was so devoted to the state and its people. I should specially mention something unique about his service to the state. Late Mr. Ranasinghe Premadasa who initiated GAM UDAWA project said, “when someone has a roof and four walls he or she can live. When you build houses you build a village, and when you build houses you build road for the village, then you will have electricity, water supply, medical Centre, community hall respectively”. This idea brought the country forward. GAM UDAWA project was instrumental in boosting the development of the country. This evolution of shelter policy is being followed by his son Sajith Premadasa. He too had built many model villages and housing schemes in different part of the island. I wish and pray that his passion for mankind will carve a path to a glorious victory.
Sri Lanka Finance Ministry is reportedly preparing to introduce new regulations to enable those pawning their gold to obtain the maximum value.
A high official from the Finance Ministry said that a circular regarding this issue is being prepared now.
It is revealed that the government is preparing to provide certain guarantees against the risks to banks and financial institutions in paying the maximum amount to those pawning their gold.
When the gold prices in the world market fell recently banks and financial institutions in Sri Lanka which had provided more loans against gold faced grave risks.
Sri Lanka pawning (gold-backed loans) credit from the banking system had grown rapidly as most of the middle class families have pawned their gold jewelry to meet their day to days due to severe economic difficulties in high cost of living conditions.
Owing to the ongoing economic crisis, gold worth nearly Rs. 200 billion has been pawned to various financial institutions in the country, a survey has revealed.
Accordingly, as per a survey conducted by the University of Peradeniya’s Department of Economics and Statistical Studies, it was revealed that gold worth over Rs. 193 billion has been pawned within the first 10 months of 2022.
The Department’s Prof. Wasantha Athukorala revealed that a majority of those who had pawned their gold belonged to the middle class, adding the two most common uses of the money received was for the education of their children and agricultural activities.
Prof. Athukorala further noted, however, that people are more likely to obtain the service from privatized pawning centres now, as they provide higher rates. The survey was conducted on a total of 13 licensed commercial banks and 10 pawning centres
The recent reversal in gold’s fortunes could prove painful for Sri Lankan banks, says a report by a leading rating agency
As gold prices soared over the past few years, Sri Lanka’s banks substantially expanded their pawning loans (gold-backed loans).
The competitive nature and need for a rapid turnaround in the pawning business could compromise the ability of banks to perform thorough credit assessment of borrowers, including checking their credit histories recorded with the Credit Information Bureau of Sri Lanka.
Banks’ pawning loans grew at a steep average annual rate of about 50 per cent over the past three years, compared with average annual loan growth of 25 per cent for the banking industry.
Sri Lankan government is aiming to speed up public investment disbursement for projects which generates return on investment to further economic growth post-pandemic as the country opens up in 2023.
Disbursing public investment capital is vital for the country’s economic recovery as it looks to bounce back from the negative effects of the pandemic and slowdown in its economy.
The expenditure on infrastructure development in priority areas covering highways, water supply, irrigation, transport, and agriculture and education sectors was nearly Rs. 210 billion in the first nine months of 2022.
A sum of Rs. 114 billion has been allocated o for the development of roads,highways, bridges and expressways, Rs. 15 billion for ensuring adequate and safe drinking water for all and Rs. 31 billion for improving efficiency, capacity and connectivity of the transport network
Feather a sum of Rs. 11 billion has been set apart for improving productivity and efficiency of the agriculture value chain by introducing modern technology and introducing new seeds varieties, Rs. 28 billion for ensuring water availability for agriculture by constructing multipurpose irrigation schemes and canals
Rs.11 billion will be spent for infrastructure development and quality improvement of the education system the investment projects take time to implement. Hence, ramping up of safe infrastructure maintenance is advisable rather than going for new projects during the pandemic. Finance ministry public investment report on 2022 projects reveled.
These ongoing projects will providence benefits immediately for the people and investments are made in the most productive sectors, senior treasury official said.
Hence, committed projects could be reviewed/restructured and consider relaunching of halted/delayed projects due to pandemic situation. In 2020, only 40 projects out of 100 projects in the pipeline were implemented due to island wide lock-down.
For 2021, 90 projects have been identified as priority projects for implementation. The total investment for new projects during 2022-2024 is Rs. 234 billion and this accounts to 8 percent of the to all investment, the report disclosed.
As such, priority needs to be given to projects that addresses the post crisis recovery needs.
Accordingly, the main purpose of the PIP 2021-2024 is to achieve the development targets of the government and the United Nations Agenda 2030.
Financing the investment projects is crucial considering the high debt burden and uncertainties in the speed of the recovery.
Hence, non-debt financing options such as FDIs, green bonds etc. should be encouraged. Moreover, the United Nations 2030 Agenda provides a blueprint to achieve a more sustainable future for all.
The Food and Agriculture Organization of the United Nations (FAO) and the United Nations Office on Drugs and Crime (UNODC) are working with the Department of Prisons in Sri Lanka to enhance the skills of inmates in modern agriculture practices.
Accordingly, a selection of agricultural land under the Mahara Prison and the Pallansena Youth Correctional Center is being utilized to establish sustainable farming structures.
FAO and UNODC are providing technical equipment such as greenhouses, irrigation systems including solar water pump and sprinkler systems, and mushroom cultivation units along with training on sustainable agriculture practices for inmates and officials engaged in agriculture within these prisons.
The officials and inmates will be granted certificates to recognize the skills developed as part of the project and support the inmates’ access to livelihoods in the agriculture sector at the point of reintegration into society.
The Commissioner–General of Prisons, Thusara Upuldeniya describing the added value of the initiative stated “Inmates must be provided opportunities to develop their skills in a meaningful way to ensure successful re-integration into society.
The modern farming structures at the correctional facilities will also help strengthen the food security of the inmates. We thank FAO and UNODC for its support.”
Speaking on the initiative FAO Representative for Sri Lanka and the Maldives, Mr Vimlendra Sharan stated “As FAO we are committed to encouraging urban agriculture by developing skills and promoting livelihoods in the agriculture sector.
The technical knowledge and skills transferred through this project will support the participants by providing expanded employment opportunities in the agriculture sector at the point of reintegration into society.”
Speaking on UNODC’s commitment, UNODC Head of Office a.i., Ms Siri Bjune stated “UNODC’s Global Maritime Crime Programme is committed to further support Sri Lanka Prisons to improve their capacities in managing secure, sustainable and human rights compliant detention facilities, that also promote effective rehabilitation.
UNODC would like to see this project contributes toward improved mental and physical well-being of the prisoners and further encourages Sri Lanka to meet international standards in treatment of prisoners and prison facilities.”
Below is a remark on President Ranil Wickremesinghe’s intervention of providing a political solution to the Ethnic Crisis faced by the Tamil communities of the North and the East by initiating several rounds of discussions having all political parties involved as stakeholders.
It would be an unavoidable fact that the National Crisis facing Sri Lanka, which at one point heated the arena in the form of a political crisis and at another an armed struggle for three decades, has taken a drastic turn influenced by the economic meltdown affecting the lives of the people of Sri Lanka regardless of their ethnicity. In the backdrop, the island nation is suffering from its worst economic crisis since independence, a scenario that can only be solved by the help of the International Community and more importantly, the Sri Lankan Tamil Community living overseas.
The extent to which the Economic Crisis facing Sri Lanka is solved will be decided by the extent to which the International Community wishes to extend their support to us, and the scenario of Sri Lankans being compelled to suffer further and for how long will be on their hands. The fact that many Sri Lankan regimes throughout the course of time breaking the promises made before the United Nations Human Rights Council and India during and after the thirty-year war leading the International Community to grow negative towards the island nation remains intact, and it is only fair that they may hold doubts about the sincerity of the Government of Sri Lanka catering especially to the National Crisis.
Sri Lanka being the paradigm of being relentlessly divided against the Political Crisis in the eyes of the International Community may give them no pleasure to support us to solve the Economic Crisis, unless the political leaders step up sparing differences. The International Community may have no interest in supporting a nation that has no willingness to settle its own political grudges. We, therefore, must open the door that provides solutions to the National Crisis by ourselves first, are we to solve the Economic Crisis.
Be the fact that the incumbent President of Sri Lanka is a person who is capable of leading the mission of solving the crisis true, Ranil Wickremesinghe has always been in the political view of providing solutions to the National Crisis by ‘power devolution’, against every backlash of him being labelled as a pro-LTTEer.
During the presidency of Chandrika Bandaranaike Kumaratunga, she also tendered the resolution of power devolution, which at the time did not receive the support of the United National Party (UNP) led by Wickremesinghe. On another occasion, political streams like the Sri Lanka Freedom Party (SLFP) and the Janatha Vimukthi Peramuna (JVP) opposed the peace establishment process initiated by Wickremesinghe. Despite the history being arguable, today Wickremesinghe does hold the position of Executive President of Sri Lanka and is administering the country alongside the Sri Lanka Podujana Peramuna (SLPP), or commonly known as the ‘Pohottuwa,’ a faction that unplugged itself from the SLFP mainstream after the 2015 Mahinda Rajapaksa defeat. The combination would be very crucial at this time, given that Sri Lanka may have been left with no more options.
Notwithstanding what is laid down above, there is also a standalone fighter in Parliament who is very much capable of boosting the process of solving the National Crisis by becoming a bridge between the Tamil political parties of the North and the East and the political parties of the South. He is none other than Dr. Rajitha Senaratne, a senior politician representing the Parliament of Sri Lanka for decades who has always been a huge voice for the minority communities of the country. His vision has also stood for providing a political solution to the National Crisis, despite his decisions to switch parties from which he contested throughout the years. During his tenure as a Cabinet Minister in the out and loud racist regime led by Mahinda Rajapaksa, Dr. Senaratne never changed his belief of providing a political solution to the National Crisis. The former Health Minister may have been ridiculed by the nationalists and their overwhelming followers, but Senaratne had never betrayed his vision towards any force that had stood against him. Needless to say, that the Tamil political parties can lay their trust upon him.
Almost every occasion on which a political solution was sought to solve the National Crisis, racist political powers of the South called it an attempt to divide the country. Contradictory to what the vast majority devoted to the South-led political stream believes, the Tamil National Alliance (TNA) led by R. Sampanthan has made it very clear that they have no intention of dividing the country at all, but the implementation of power devolution, especially in the backdrop that there is no more LTTE separatism in the island nation. The TNA’s stance easily debunks the South-led political forces’ argument of dividing the country.
Reminiscent of the famous catchphrase by John Dickinson, the founding father of the United States, “United We Stand, Divided We Fall,” us the Sri Lankans too have to make a very unpopular decision as to whether we should stand up together to solve the Political and Economic Crises of the country by sparing our prejudice for the sake of the future generations, or should we continue to divide ourselves losing this golden opportunity once and for all.
*Adapted by original article, “ජාතික ගැටලුවට විසඳුමක් සෙවීමට මේ ස්වර්ණමය අවස්ථාව මඟ නොහරිමු !” published on 11.12.2022
Sri Lankan worker remittances revenue continued its ascent in November for the third month in succession reflecting end of the poor run of the key foreign currency inflow, helping the dollar-starved country to fund its essential imports
Labour and Foreign Employment Minister Manusha Nanayakkara expressed his gratitude to every expatriate worker who has sent money through the banking system legally.
He said that all Sri Lankans need the support of expatriate workers at this time, with the country facing a foreign exchange shortage.
The foreign remittances are moving closer to a US$5bn in annual rate based on November monthly data. Sri Lanka remittances for the month of November totaled US$384mn, up about 10 percent from the prior months figure.
Before the economic crisis in Sri Lanka, the country used to receive over US$7bn per year in foreign remittance. This figure had dropped in half to an annualized rate of approximately US$3.5bn during the worst of the crisis.
Sri Lankans have been lining up in droves to migrate overseas for job opportunities that will allow them to earn foreign currency based salaries.
As record numbers of migrants of around 200,000 depart Sri Lanka raising expectations of rising foreign currency remittances in the medium term in future.
This, coupled with a tourism industry recovery and stable global oil price will be key to Sri Lanka’s economic recovery.
Sri Lanka’s workers’ remittance increased to US$ 384.4 million in November 2022, according to the Central Bank.
Accordingly, the cumulative figure for the first eleven months of the year (Jan – Nov) is reported as $ 3,313.9 million,
Sri Lanka had observed an increase of 12% in workers’ remittances in October 2022 compared to the inflows recorded in October 2021.
Figures released by the Central Bank (CBSL) showed that workers’ remittances had increased to $ 355.4 million in October 2022 from$317.4 million in September 2022
Sri Lanka’s officially calculated worker remittances grew 1.73 percent from a year earlier to$359.3 million in September 2022, official data showed. Official remittances were also up from $325.4 million in August.
Sri Lanka received around $446 million s in remittances in August 2021, when the central bank tightened rules on how much banks could pay for remittances.
Overseas workers send money through unofficial channels when central banks in the region print money creating pressure on outflows and then imposes exchange controls, triggering parallel exchange rates.
Chief Negotiator of Free Trade Agreements at the International Trade Office set up under the Presidential Secretariat, K J Weerasinghe says, “we hope to commence negotiations on the ETCA with India later this month”.
Around 3,000 workers from Sri Lanka Telecom, Sri Lanka Insurance Corp and the State Banks protest in Colombo, Matara, Kalutara, Badulla and Negombo, against “Privatisation”: they also protest against the Govt’s austerity measures.
IMF Chief Kristlina Georgieva says she had a “fruitful exchange” with her Chinese counterparts this week on her repeated calls for accelerating debt treatments for countries like Zambia and Sri Lanka.
President’s Senior Advisor Ruwan Wijewardene says the Japanese Govt has agreed to recommence the multi-billion dollar Light Rail Transit project funded by Japanese loans, after the conclusion of the IMF negotiations: the LRT project was abandoned in 2020 with the objective of reducing Sri Lanka’s Forex borrowings: Sri Lanka is currently facing a severe debt crisis and has defaulted on its external debt.
Ministry of Agriculture says 1,092 heads of cattle and goats have died due to the shock of prevailing cold weather in the Northern and Eastern provinces: as a consequence, President orders the suspension of the transportation of beef and mutton at district and provincial levels with immediate effect.
COPF Chairman and SJB’s Economic Guru MP Dr Harsha Silva says the COPF has approved the regulations under the Casino Business (Regulation) Act No.17 of 2010 which are expected to enable the establishment of a Casino Regulatory Authority by 30th September 2023.
President Ranil Wickremesinghe pledges to assist the University of Colombo to improve its quality: participates at the “Back to the Faculty” alumni programme at the Law Faculty as the first alumnus of the Colombo Law Faculty who became the Executive President.
Police Media Spokesman says the Police Mounted division has lost 7 horses due to feed shortage amid import bans: also says each horse is worth around USD 35,000 and there are around 50 horses that are being maintained currently.
Former CB Governor Ajith Nivard Cabraal says the Rupee had been “fixed” at around Rs.365 per USD for the past 7 months: warns the Rupee is likely to depreciate rapidly and substantially when the IMF programme commences officially and the Monetary Board is precluded by the IMF from “fixing” the Rupee thereafter.
Head of International Cricket Council’s Anti-Corruption Unit Alex Marshall to investigate allegations of match-fixing during the recent Test series between Sri Lanka and Pakistan: Sri Lanka Cricket had invited the ICC to undertake this investigation based on a claim by SJB MP Nalin Bandara in Parliament that the 2-match Test series played in July was “fixed”.